![]() So which is the case? Can malate leave/enter the mitochrondria freely? If so, what's the point of aspartate?Įdit: I think I may get it now- is it correct to say that the use of aspartate is to obviate the need for NADH (electrons)? So when malate is made from OAA, and directly leaves the mitochondria, we are essentially using up an NADH in the process? What you and a lot of other sources are saying is that malate is what leaves the cytosol. Aspartate crosses into the cytosol, and can be reconverted to oxaloacetate to restart the cycle, as shown in Figure 10.15.Įssentially they're saying Aspartate is what leaves the mitochrondria and malate is what enters it. Recycling the malate requires oxidation to oxaloacetate, which can be transaminated to form aspartate. Now that NADH is in the matrix, it can pass along its electrons to the ETC via Complex I and generate 2.5 ATP per molecule of NADH. Once malate crosses into the matrix, mitochondrial malate dehydrogenase reverses the reaction to form mitochondrial NADH. Accompanying this reduction is the oxidation of cytosolic NADH to NAD+. This is accomplished by cytosolic malate dehydrogenase. Malate–aspartate shttle: cytosolic oxaloacetate, which cannot pass through the inner mitochondrial membrane, is reduced to malate, which can. Regarding this point, Kaplan says the following when discussing the NADH electron shuttles: Once it's there, it's then converted back into oxaloacetate. Malate then crosses the membrane to go to the cytosol. ![]() /r/GAMSAT - Australian & UK Medical school Admission Test.P/S = Psychological, Social, and Biological Foundations of Behavior (Tentative) AAMC Sample FL Score ConversionĬ/P = Chemical and Physical Foundations of Biological SystemsĬARS = Critical Analysis and Reasoning Skillsī/B = Biological and Biochemical Foundations of Living Systems # Correct -> Scaled Score Converter for AAMC Material These posts will be removed and the user banned without warning, subject to the discretion of the mod team Learn MoreĪll of the above rules are subject to moderator discretion High Yield MCAT Links You have signed an examinee agreement, and it will be enforced on this subreddit.ĭo not intentionally advertise paid or free products or services of any sort. We have one "stickied" post for each exam and score release day, contain all test day discussion/reactions to that thread only.ĭo not discuss any specific information from your actual MCAT exam. For an example format for submitting pictures of questions from practice material click hereĭo not link to content that infringes on copyright laws (MCAT torrents, third party resources, etc).ĭo not post repeat "GOOD LUCK", "TEST SCORE", or test reaction posts. These are considered spoilers and should be marked as such. Be nice to each other, hating on other users won't help you get extra points on the MCAT, so why do it?ĭo not post any question information from any resource in the title of your post. Rudeness or trolling will not be tolerated. Please message the moderators with your skills/ideas! MCAT RESOURCES & INFO Study Groups Want to help us improve this subreddit or tell us about a new resource we can add to the sidebar? Below you will find our forum rules, resources, and more. ![]() We request that you read the sidebar COMPLETELY before you post. r/MCAT is a place for support, discussion, advice, social networking, news, study tips and more. The MCAT (Medical College Admission Test) is offered by the AAMC and is a required exam for admission to medical schools in the USA and Canada. Welcome to the BEST place for MCAT prep and practice materials.
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